EBI Personnel Directory Fisher, Michael
The microbial conversion of sugars to biofuels is a promising new technology, but the fuels produced are often toxic to the microbial producers. One promising solution is to alter the pumps that microbes use to secrete antibiotics and other toxic chemicals to secrete the fuel product out of the cell instead. Understanding the natural diversity of such pumps and how to modify them for the efflux of desired chemicals will be critical for successful microbial biofuel production. Tullman-Ercek’s group will characterize and genetically optimize protein-based efflux pumps to secrete two important classes of biofuels from gram-negative bacteria.